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Collaboration Agreements - Sanofi, Antibody Narrative (Details) - USD ($)
$ in Millions
3 Months Ended 6 Months Ended
Jun. 30, 2019
Mar. 31, 2019
Jun. 30, 2018
Jun. 30, 2019
Jun. 30, 2018
Disaggregation of Revenue [Line Items]          
Research and development $ 1,048.3   $ 529.3 $ 1,690.1 $ 1,027.9
Cost of Treasury stock shares received   $ 54.0 37.6    
Sanofi Collaboration Agreement, Antibody          
Disaggregation of Revenue [Line Items]          
Percentage of Trial Costs borne by collaborating party       80.00%  
Percentage of Trial Costs borne by entity       20.00%  
Treasury stock, shares acquired       24,143  
Cost of Treasury stock shares received       $ 10.0  
Maximum amount of sales milestone payments if total sales achieve specific levels       250.0  
Levels of twelve month sales at which sales milestone payments would be received       $ 1,000.0  
Period for achieving sales target for milestone payment, rolling basis       12 months  
Praluent, Kevzara, and Dupixent | Sanofi Collaboration Agreement, Antibody          
Disaggregation of Revenue [Line Items]          
Research and development $ 10.3   $ 9.9 $ 19.6 $ 23.8