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Stockholders' Equity - Narrative (Details)
1 Months Ended 12 Months Ended
Dec. 31, 2007
shares
Dec. 31, 2018
vote
demand_right
$ / shares
shares
Jan. 07, 2018
shares
Dec. 31, 2017
$ / shares
shares
Class of Stock [Line Items]        
Preferred stock, shares authorized (in shares)   30,000,000   30,000,000
Number of demand rights to require the Company to conduct registered underwritten public offering | demand_right   3    
Maximum shares the collaborator could sell (in shares)   1,173,847 1,400,000  
Class A Stock        
Class of Stock [Line Items]        
Common Stock, shares authorized (in shares)   40,000,000   40,000,000
Common Stock, par value (in dollars per share) | $ / shares   $ 0.001   $ 0.001
Number of votes per share | vote   10    
Common Stock        
Class of Stock [Line Items]        
Common Stock, shares authorized (in shares)   320,000,000   320,000,000
Common Stock, par value (in dollars per share) | $ / shares   $ 0.001   $ 0.001
Number of votes per share | vote   1    
Sanofi        
Class of Stock [Line Items]        
Number of shares of Common Stock purchased 12,000,000      
Maximum percentage of outstanding shares that may be acquired, under 'standstill' provisions   30.00%    
Percentage of outstanding shares or voting rights under amended investor agreement   20.00%    
Percentage of outstanding shares that the Company is required to appoint an individual agreed upon by the Company and the Collaborator to the Company's board of directors   20.00%    
Bayer        
Class of Stock [Line Items]        
Maximum percentage of outstanding shares that may be acquired, under 'standstill' provisions   20.00%    
Teva        
Class of Stock [Line Items]        
Maximum percentage of outstanding shares that may be acquired, under 'standstill' provisions   5.00%