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Collaboration and License Agreements - Schedule of Significant Changes in Deferred Revenue Balances, IO Collaboration (Details) - USD ($)
$ in Millions
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Disaggregation of Revenue [Line Items]      
Increase as a result of cumulative-effect adjustment arising from the adoption of ASC 606 $ (194.5) $ (113.1) $ 244.3
Sanofi Collaboration Agreement, Immuno-oncology      
Disaggregation of Revenue [Line Items]      
Revenue recognized that was included in deferred revenue at the beginning of the period (108.7)    
Accounting Standards Update 2014-09 | Sanofi Collaboration Agreement, Immuno-oncology      
Disaggregation of Revenue [Line Items]      
Increase as a result of cumulative-effect adjustment arising from the adoption of ASC 606 $ 93.6