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Property, Plant, and Equipment (Tables)
 12 Months Ended
Dec. 31, 2018
Property, Plant and Equipment [Abstract]  
Schedule of Property, Plant and Equipment
Property, plant, and equipment consists of the following:
 
As of December 31,
 
2018
 
2017
Land
$
199.0

 
$
192.8

Building and improvements
1,507.2

 
1,441.6

Leasehold improvements
97.0

 
102.6

Construction-in-progress
469.6

 
408.9

Laboratory and other equipment
773.7

 
599.1

Furniture, computer and office equipment, and other
258.0

 
179.9

 
3,304.5

 
2,924.9

Less, accumulated depreciation and amortization
(728.7
)
 
(566.3
)
 
$
2,575.8

 
$
2,358.6