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Statement of Cash Flows Narrative (Details) - USD ($)
$ in Millions
6 Months Ended
Jun. 30, 2018
Jun. 30, 2017
Dec. 31, 2017
Dec. 31, 2016
Condensed Cash Flow Statements, Captions [Line Items]        
Accrued capital expenditures $ 38.4 $ 30.9 $ 41.8 $ 28.2
Cost of Treasury stock shares received $ 37.6      
Capital lease obligations incurred   $ 201.2    
Sanofi Collaboration Agreement, Immuno-oncology        
Condensed Cash Flow Statements, Captions [Line Items]        
Treasury stock, shares acquired 121,601