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Collaboration Agreements Bayer Narrative (Details) - Bayer - USD ($)
$ in Millions
 3 Months Ended 6 Months Ended
Dec. 31, 2017
Jun. 30, 2018
Ang2 Antibody    
Disaggregation of Revenue [Line Items]    
Up-front payment received $ 50.0  
Minimum    
Disaggregation of Revenue [Line Items]    
Revenue based on percentage of annual sales in Japan   33.50%
Maximum    
Disaggregation of Revenue [Line Items]    
Revenue based on percentage of annual sales in Japan   40.00%