Property, Plant, and Equipment (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Property, Plant and Equipment [Line Items]
Land, Gross	$ 192,757	$ 103,906
Buildings and Improvements, Gross	1,441,565	1,278,283
Leasehold Improvements, Gross	102,599	101,101
Construction in Progress, Gross	408,857	318,929
Costs incurred by the landlord to construct new laboratory and office facilities	599,153	554,181
Furniture and Fixtures, Gross	179,968	152,525
Property, plant, and equipment, gross	2,924,899	2,508,925
Less: accumulated depreciation and amortization	(566,294)	(425,504)
Property, plant, and equipment, net	2,358,605	2,083,421
Depreciation	142,200	104,700	$ 74,900
Capital and facility leases, at cost	724,100	407,100
Depreciation and amortization expense	145,467	104,745	$ 74,909
Accumulated amortization of capital and facility leases	47,900	44,000
UNITED STATES
Property, Plant and Equipment [Line Items]
Property, plant, and equipment, net	1,692,900	1,441,200
Europe [Member]
Property, Plant and Equipment [Line Items]
Property, plant, and equipment, net	$ 665,700	$ 642,200