Accounts Payable and Accrued Expenses (Tables)

12 Months Ended

Dec. 31, 2017

Payables and Accruals [Abstract]

Schedule of Accounts Payable and Accrued Liabilities

Accounts payable and accrued expenses consist of the following:

	As of December 31,
	2017		2016
Accounts payable	$	178,183	$	134,984
Accrued payroll and related costs	191,825		153,086
Accrued clinical trial expense	120,891		91,753
Accrued sales-related charges, deductions, and royalties	194,542		159,985
Income taxes payable	227		235,776
Other accrued expenses and liabilities	129,410		103,512
	$	815,078	$	879,096