Property, Plant, and Equipment (Tables)

12 Months Ended

Dec. 31, 2017

Property, Plant and Equipment [Abstract]

Property, Plant and Equipment

Property, plant, and equipment consists of the following:

	As of December 31,
	2017			2016
Land	$	192,757		$	103,906
Building and improvements	1,441,565			1,278,283
Leasehold improvements	102,599			101,101
Construction-in-progress	408,857			318,929
Laboratory and other equipment	599,153			554,181
Furniture, computer and office equipment, and other	179,968			152,525
	2,924,899			2,508,925
Less, accumulated depreciation and amortization	(566,294		)	(425,504		)
	$	2,358,605		$	2,083,421