Property, Plant, and Equipment

12 Months Ended

Dec. 31, 2017

Property, Plant and Equipment [Abstract]

Property, Plant and Equipment

Property, Plant, and Equipment

Property, plant, and equipment consists of the following:

	As of December 31,
	2017			2016
Land	$	192,757		$	103,906
Building and improvements	1,441,565			1,278,283
Leasehold improvements	102,599			101,101
Construction-in-progress	408,857			318,929
Laboratory and other equipment	599,153			554,181
Furniture, computer and office equipment, and other	179,968			152,525
	2,924,899			2,508,925
Less, accumulated depreciation and amortization	(566,294		)	(425,504		)
	$	2,358,605		$	2,083,421

As of December 31, 2017 and 2016, $1,692.9 million and $1,441.2 million, respectively, of the Company's net property, plant, and equipment was located in the United States and $665.7 million and $642.2 million, respectively, was located in Europe (primarily in Ireland).

Depreciation and amortization expense (including amortization expense related to capital and facility leases) on property, plant, and equipment amounted to $142.2 million, $104.7 million, and $74.9 million for the years ended December 31, 2017, 2016, and 2015, respectively.

Property, plant, and equipment, at cost, as of December 31, 2017 and 2016 included $724.1 million and $407.1 million, respectively, of leased property under the Company's capital and facility leases at its Tarrytown, New York facility. See Note 12. Accumulated amortization related to these assets amounted to $47.9 million and $44.0 million as of December 31, 2017 and 2016, respectively.