Accounts Payable and Accrued Expenses (Details) - USD ($) $ in Thousands	Jun. 30, 2017	Dec. 31, 2016
Accounts Payable and Accrued Liabilities, Current [Abstract]
Accounts payable	$ 151,372	$ 134,984
Accrued payroll and related costs	146,438	153,086
Accrued clinical trial expense	101,570	91,753
Accrued sales-related charges, deductions and royalties	214,374	159,985
Taxes Payable, Current	23,240	235,776
Other accrued expenses and liabilities	79,370	103,512
Accounts payable and accrued expenses	$ 716,364	$ 879,096