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Collaboration Agreements (Sanofi) (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended 12 Months Ended
Jun. 30, 2017
Jun. 30, 2016
Sep. 30, 2015
Jun. 30, 2017
Jun. 30, 2016
Dec. 31, 2017
Dec. 31, 2016
Collaboration Agreement [Line Items]              
Revenue from Related Parties $ 222,128 $ 163,414   $ 432,495 $ 383,108    
Research and development 509,975 559,930   1,017,410 1,030,042    
Deferred Revenue From Related Party Current 184,452     184,452     $ 115,267
Antibody Collaboration              
Collaboration Agreement [Line Items]              
Net profit (loss) from commercialization of products under collaboration agreement (122,281) (122,107)   (230,683) (221,529)    
Reimbursement of Regeneron research and development expenses 137,272 144,232   292,517 337,834    
Reimbursement Revenue 87,104 80,817   160,663 149,539    
Contracts Revenue 31,204 8,122   42,490 15,639    
Revenue from Related Parties 133,299 111,064   $ 264,987 281,483    
Percentage of Trial Costs borne by collaborating party       80.00%      
Percentage of Trial Costs borne by entity       20.00%      
IO Discovery Agreement              
Collaboration Agreement [Line Items]              
Annual Funding Maximum of Research Activities Per Agreement       $ 200,000      
IO Agreement              
Collaboration Agreement [Line Items]              
Deferred Revenue, Additions     $ 640,000        
Immuno-oncology Agreement              
Collaboration Agreement [Line Items]              
Reimbursement of Regeneron research and development expenses 68,080 32,350   126,759 61,625    
Contracts Revenue 20,749 20,000   40,749 40,000    
Revenue from Related Parties 88,829 52,350   167,508 101,625    
Praluent, sarilumab, and dupilumab [Member] | Antibody Collaboration              
Collaboration Agreement [Line Items]              
Research and development $ 20,600 $ 30,600   $ 45,600 $ 52,300    
Scenario, Forecast [Member] | Antibody Collaboration              
Collaboration Agreement [Line Items]              
Annual funding maximum of research activities per amended agreement           $ 130,000