Accounts Payable and Accrued Expenses (Details) - USD ($) $ in Thousands	Mar. 31, 2017	Dec. 31, 2016
Accounts Payable and Accrued Liabilities, Current [Abstract]
Accounts payable	$ 141,801	$ 134,984
Accrued payroll and related costs	94,088	153,086
Accrued clinical trial expense	92,474	91,753
Accrued sales-related charges, deductions and royalties	183,561	159,985
Taxes Payable, Current	450,805	235,776
Other accrued expenses and liabilities	99,048	103,512
Accounts payable and accrued expenses	$ 1,061,777	$ 879,096