Deferred Revenue (Details) - USD ($) $ in Thousands	Dec. 31, 2016	Dec. 31, 2015
Current portion:
Deferred revenue, current portion	$ 231,664	$ 153,487
Deferred revenue - other, current portion	116,397	51,914
Long-term portion:
Deferred revenue, long-term portion	830,772	664,679
Deferred revenue - other	327,298	82,015
Received or receivable from Sanofi
Current portion:
Deferred revenue, current portion		101,573
Long-term portion:
Deferred revenue, long-term portion		582,664
Received or receivable from Bayer HealthCare
Current portion:
Deferred revenue, current portion	31,084	24,290
Long-term portion:
Deferred revenue, long-term portion	77,028	31,926
Mitsubishi Tanabe Pharma Corporation (MTPC) [Member]
Current portion:
Deferred revenue, current portion	9,188	2,352
Long-term portion:
Deferred revenue, long-term portion	45,940	7,059
Teva Pharmaceuticals [Member]
Current portion:
Deferred revenue, current portion	43,122	0
Long-term portion:
Deferred revenue, long-term portion	194,050	0
Received for technology license agreement
Current portion:
Deferred revenue, current portion	23,572	23,572
Long-term portion:
Deferred revenue, long-term portion	10,280	33,851
Other
Current portion:
Deferred revenue, current portion	9,431	1,700
Long-term portion:
Deferred revenue, long-term portion	$ 0	$ 9,179