Accounts Payable and Accrued Expenses (Details) - USD ($) $ in Thousands	Dec. 31, 2016	Dec. 31, 2015
Accounts Payable and Accrued Liabilities, Current [Abstract]
Accounts payable	$ 134,984	$ 140,962
Accrued payroll and related costs	153,086	133,223
Accrued clinical trial expense	91,753	88,297
Accrued sales-related charges, deductions and royalties	159,985	195,986
Taxes Payable, Current	235,776	0
Other accrued expenses and liabilities	103,512	85,644
Accounts payable and accrued expenses	$ 879,096	$ 644,112