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Technology Licensing Agreements (Details) - License Agreement with Astellas Pharma Inc. - USD ($)
$ in Millions
1 Months Ended 12 Months Ended
Aug. 31, 2010
Mar. 31, 2007
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Deferred Revenue Arrangement [Line Items]          
Non-exclusive license agreement term   6 years      
Advance payment received due to amended licensing agreement $ 165.0        
Recognition period for advance payment 7 years        
Future payment to be made under terms of amended licensing agreement     $ 130.0    
Number of days of advance written notice to terminate agreement     90 days    
Technology licensing revenue     $ 23.6 $ 23.6 $ 23.6
Deferred Revenue     $ 33.9 $ 57.4