Net Product Sales (Tables)

12 Months Ended

Dec. 31, 2016

Schedules of Concentration of Risk, by Risk Factor

The Company's product sales to certain customers that accounted for more than 10% of total gross product revenue for each of the years ended December 31, 2016, 2015, and 2014. Sales to each of these customers as a percentage of the Company's total gross product revenue are as follows:



	Year Ended December 31,
	2016		2015		2014
Besse Medical, a subsidiary of AmerisourceBergen Corporation	55	%	67	%	73	%
McKesson Corporation	28	%	26	%	20	%
Curascript SD Specialty Distribution, a subsidiary of Express Scripts	16	%	**		**

** For the periods ending December 31, 2015 and 2014, sales to Curascript SD Specialty Distribution represented less than 10% of total gross product revenue.

Sales Related Deductions Activity

The following table summarizes the provisions, and credits/payments, for these sales-related deductions for the years ended December 31, 2016, 2015, and 2014.



	Rebates & Chargebacks			Distribution- Related Fees			Other Sales- Related Deductions			Total
Balance as of December 31, 2013	$	4,400		$	19,663		$	538		$	24,601
Provision related to current period sales	33,117			77,160			1,578			111,855
Credits/payments	(34,434		)	(75,657		)	(1,584		)	(111,675		)
Balance as of December 31, 2014	3,083			21,166			532			24,781
Provision related to current period sales	61,124			122,466			9,600			193,190
Credits/payments	(57,788		)	(95,319		)	(9,615		)	(162,722		)
Balance as of December 31, 2015	6,419			48,313			517			55,249
Provision related to current period sales	93,385			154,477			30,442			278,304
Credits/payments	(87,092		)	(173,325		)	(27,285		)	(287,702		)
Balance as of December 31, 2016	$	12,712		$	29,465		$	3,674		$	45,851