Accounts Payable and Accrued Expenses (Details) - USD ($) $ in Thousands	Sep. 30, 2016	Dec. 31, 2015
Accounts Payable and Accrued Liabilities, Current [Abstract]
Accounts payable	$ 124,497	$ 140,962
Accrued payroll and related costs	139,722	133,223
Accrued clinical trial expense	82,269	88,297
Accrued sales-related charges, deductions and royalties	129,485	195,986
Taxes Payable, Current	155,485	0
Other accrued expenses and liabilities	83,458	85,644
Accounts payable and accrued expenses	$ 714,916	$ 644,112