Accounts Payable and Accrued Expenses (Details) - USD ($) $ in Thousands	Jun. 30, 2016	Dec. 31, 2015
Accounts Payable and Accrued Liabilities, Current [Abstract]
Accounts payable	$ 101,721	$ 140,962
Accrued payroll and related costs	114,603	133,223
Accrued clinical trial expense	88,639	88,297
Accrued sales-related charges, deductions and royalties	177,377	195,986
Taxes Payable, Current	170,269	0
Other accrued expenses and liabilities	107,034	85,644
Accounts payable and accrued expenses	$ 759,643	$ 644,112