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Collaboration Agreements (EYLEA) (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2015
Mar. 31, 2015
Jun. 30, 2016
Jun. 30, 2015
Collaboration Agreement [Line Items]        
Period for Achieving Sales Target for Milestone Payment, Rolling Basis   12 months    
sales achievement - $200 million        
Collaboration Agreement [Line Items]        
Revenue Recognition, Milestone Method, Revenue Recognized   $ 15,000    
Collaboration Agreement with Bayer        
Collaboration Agreement [Line Items]        
Revenue Recognition, Milestone Method, Revenue Recognized     $ 0 $ 15,000
Levels of twelve month sales at which sales milestone payments were received - 200 million   $ 200,000    
PDGF        
Collaboration Agreement [Line Items]        
Revenue Recognition, Milestone Method, Revenue Recognized $ 5,000      
Minimum [Member] | Collaboration Agreement with Bayer        
Collaboration Agreement [Line Items]        
Revenue based on percentage of annual sales in Japan     33.50%  
Maximum [Member] | Collaboration Agreement with Bayer        
Collaboration Agreement [Line Items]        
Revenue based on percentage of annual sales in Japan     40.00%