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Net Product Sales (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2016
Jun. 30, 2015
Jun. 30, 2016
Jun. 30, 2015
Dec. 31, 2015
Dec. 31, 2014
Revenue Disclosure [Line Items]            
Net product sales $ 834,219 $ 657,819 $ 1,618,401 $ 1,202,392    
Activity of Sales Related Deductions [Roll Forward]            
Balance 40,846 45,458 40,846 45,458 $ 55,249 $ 24,781
Provision related to current period sales     127,956 83,682    
Credits/payments     (142,359) (63,005)    
Rebates and Chargebacks            
Activity of Sales Related Deductions [Roll Forward]            
Balance 11,635 5,474 11,635 5,474 6,419 3,083
Provision related to current period sales     41,326 25,481    
Credits/payments     (36,110) (23,090)    
Distribution Related Fees            
Activity of Sales Related Deductions [Roll Forward]            
Balance 28,135 39,480 28,135 39,480 48,313 21,166
Provision related to current period sales     74,289 54,747    
Credits/payments     (94,467) (36,433)    
Other Sales Related Deductions            
Activity of Sales Related Deductions [Roll Forward]            
Balance $ 1,076 $ 504 1,076 504 $ 517 $ 532
Provision related to current period sales     12,341 3,454    
Credits/payments     $ (11,782) $ (3,482)    
Customer concentration risk | Gross Sales Revenue            
Risks and Uncertainties [Abstract]            
Concentration risk, percentage 56.00% 69.00% 58.00% 69.00%    
EYLEA            
Revenue Disclosure [Line Items]            
Net product sales $ 830,900 $ 654,600 $ 1,611,800 $ 1,195,700    
ARCALYST            
Revenue Disclosure [Line Items]            
Net product sales $ 3,300 $ 3,200 $ 6,600 $ 6,700