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Inventory (Notes)
6 Months Ended
Jun. 30, 2016
Inventory Disclosure [Abstract]  
Inventory
Inventories
Inventories consist of the following:
 
June 30,
 
December 31,
 
2016
 
2015
Raw materials
$
73,971

 
$
59,151

Work-in-process
165,869

 
132,068

Finished goods
14,421

 
11,197

Deferred costs
61,812

 
36,162

 
$
316,073

 
$
238,578


Deferred costs represent the costs of product manufactured and shipped to the Company's collaborators for which recognition of revenue has been deferred. For the three months ended June 30, 2016 and 2015, cost of goods sold included inventory write-downs and reserves totaling $2.0 million and $6.4 million, respectively. For the six months ended June 30, 2016 and 2015, cost of goods sold included inventory write-downs and reserves totaling $6.3 million and $8.1 million, respectively.