CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2016	Mar. 31, 2015
Cash flows from operating activities:
Net income	$ 165,736	$ 76,021
Adjustments to reconcile net income to net cash provided by (used in) operating activities:
Depreciation and amortization	22,977	16,027
Non-cash compensation expense	142,250	103,759
Other non-cash charges and expenses, net	3,957	8,808
Deferred taxes	(79,785)	(37,256)
Changes in assets and liabilites
Increase in Sanofi, Bayer, and trade accounts receivable	(397,428)	(329,746)
Increase in Inventories	(62,263)	(5,434)
Decrease in prepaid expenses and other assets	39,260	43,434
Increase (decrease) in deferred revenue	91,205	(7,457)
Increase in accounts payable, accrued expenses and other liabilities	103,431	30,117
Total adjustments	(136,396)	(177,748)
Net cash provided by (used in) operating activities	29,340	(101,727)
Cash flows from investing activities:
Purchases of marketable securities	0	(95,775)
Sales or maturities of marketable securities	60,409	80,456
Capital expenditures	(104,094)	(114,162)
Net cash used in investing activities	(43,685)	(129,481)
Cash flows from financing activities:
(Payments) proceeds in connection with facility lease obligations	(598)	6,738
Repayments of convertible senior notes	(1,739)	(16,686)
Payments in connection with deduction of outstanding warrants	(242,117)	(124,531)
Proceeds from issuance of Common Stock	39,304	76,273
Payments in connection with Common Stock tendered for employee tax obligations	(1,042)	(21,192)
Excess tax benefit from stock-based compensation	15,649	169,794
Net cash (used in) provided by financing activities	(190,543)	90,396
Net decrease in cash and cash equivalents	(204,888)	(140,812)
Cash and cash equivalents at beginning of period	809,102	648,719
Cash and cash equivalents at end of period	$ 604,214	$ 507,907