Accounts Payable and Accrued Expenses (Details) - USD ($) $ in Thousands	Mar. 31, 2016	Dec. 31, 2015
Accounts Payable and Accrued Liabilities, Current [Abstract]
Accounts payable	$ 120,595	$ 140,962
Accrued payroll and related costs	92,668	133,223
Accrued clinical trial expense	82,533	88,297
Accrued sales-related charges, deductions and royalties	190,763	195,986
Taxes Payable, Current	144,078	0
Other accrued expenses and liabilities	102,639	85,644
Accounts payable and accrued expenses	$ 733,276	$ 644,112