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Collaboration Agreements (EYLEA) (Details) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2016
Mar. 31, 2015
Collaboration Agreement [Line Items]    
Period for Achieving Sales Target for Milestone Payment, Rolling Basis   12 months
sales achievement - $200 million    
Collaboration Agreement [Line Items]    
Revenue Recognition, Milestone Method, Revenue Recognized   $ 15,000
Collaboration Agreement with Bayer    
Collaboration Agreement [Line Items]    
Revenue Recognition, Milestone Method, Revenue Recognized $ 0 15,000
Levels of twelve month sales at which sales milestone payments were received - 200 million   $ 200,000
Minimum [Member] | Collaboration Agreement with Bayer    
Collaboration Agreement [Line Items]    
Revenue based on percentage of annual sales in Japan 33.50%  
Maximum [Member] | Collaboration Agreement with Bayer    
Collaboration Agreement [Line Items]    
Revenue based on percentage of annual sales in Japan 40.00%