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Net Income (Loss) Per Share (Details) - USD ($)
$ / shares in Units, shares in Thousands, $ in Thousands
3 Months Ended 12 Months Ended
Dec. 31, 2015
Sep. 30, 2015
Jun. 30, 2015
Mar. 31, 2015
Dec. 31, 2014
Sep. 30, 2014
Jun. 30, 2014
Mar. 31, 2014
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Earnings Per Share [Abstract]                      
Net income $ 154,994 $ 210,398 $ 194,643 $ 76,021 $ 90,095 $ 83,375 [1] $ 96,351 $ 68,305 $ 636,056 $ 338,126 $ 413,738
Weighted Average Number of Shares Outstanding Reconciliation [Abstract]                      
Weighted average shares outstanding - basic                 103,061 100,612 97,917
Effect of dilutive securities (in shares):                      
Stock options                 9,446 9,440 10,233
Restricted stock                 477 425 433
Warrants                 2,246 2,936 2,707
Dilutive potential shares                 12,169 12,801 13,373
Weighted average shares - diluted (in shares)                 115,230 113,413 111,290
Earnings Per Share, Basic and Diluted [Abstract]                      
Net income per share - basic $ 1.49 $ 2.04 $ 1.89 $ 0.74 $ 0.89 $ 0.83 $ 0.96 $ 0.69 $ 6.17 $ 3.36 $ 4.23
Net income per share - diluted $ 1.34 $ 1.82 $ 1.69 $ 0.66 $ 0.78 $ 0.73 $ 0.85 $ 0.61 $ 5.52 $ 2.98 $ 3.72
Stock options                      
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]                      
Weighted average number of shares                 1,343 1,470 304
Convertible senior notes                      
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]                      
Weighted average number of shares                 994 4,247 4,761
[1] Net income in the third quarter of 2014 included a $40.6 million incremental charge related to the Branded Prescription Drug Fee based on final regulations issued by the IRS in July 2014 as described in Note 2 above.