Income Taxes (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Operating Loss Carryforwards [Line Items]
Income (Loss) from Continuing Operations before Equity Method Investments, Income Taxes, Extraordinary Items, Noncontrolling Interest	$ 1,225,097	$ 761,235	$ 696,382
Current:
Federal	686,561	437,038	196,527
State	28,568	28,718	23,489
Current Foreign Tax Expense (Benefit)	4,004	2,879	433
Total current tax expense	719,133	468,635	220,449
Deferred:
Federal	(119,849)	(62,932)	53,504
State	(3,768)	18,891	8,700
Deferred Foreign Income Tax Expense (Benefit)	(6,475)	(1,485)	(9)
Total deferred tax (benefit) expense	(130,092)	(45,526)	62,195
Total income tax expense (benefit)	$ 589,041	$ 423,109	$ 282,644
Effective Income Tax Rate, Continuing Operations, Tax Rate Reconciliation [Abstract]
U.S. federal statutory tax rate	35.00%	35.00%	35.00%
State and local income taxes	1.00%	2.40%	3.40%
Change in state effective rate	(0.10%)	2.90%	0.00%
Foreign income tax rate differential	12.20%	15.80%	4.90%
Income tax credits	(1.60%)	(5.10%)	(4.90%)
Non-deductible Branded Prescription Drug Fee	2.00%	2.80%	1.10%
Effective Income Tax Rate Reconciliation, Deduction, Qualified Production Activity, Percent	(3.20%)	(0.00%)	(0.00%)
Other permanent differences	2.80%	1.80%	1.10%
Effective income tax rate	48.10%	55.60%	40.60%
Deferred tax assets:
Net operating loss carryforward	$ 140	$ 150
Fixed assets	0	8,078
Deferred revenue	51,766	60,223
Deferred compensation	349,508	216,640
Income tax credit carryforwards	0	8,539
Capitalized research and development costs	7,725	12,908
Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals, Accrued Liabilities	47,520	19,331
Other	26,580	21,922
Deferred tax assets, gross	483,239	347,791
Valuation allowance	0	(359)
Deferred tax assets, net	483,239	347,432
Deferred tax liabilities:
Accruals	(3,280)	(28,186)
Deferred Tax Liabilities, Property, Plant and Equipment	(5,559)	0
Convertible senior notes	0	(252)
Deferred Tax Liabilities, Other	(12,455)	(3,578)
Deferred tax liabilities, gross	(21,294)	(32,016)
Deferred Tax Assets, Net	461,945	315,416
Utilization of net operating loss carryforwards related to exercises of Nonqualified Stock Options and disqualifying dispositions of ISOs, credited to additional paid-in capital	405,317	439,278	$ 211,909
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Amount			34,000
Unrecognized Tax Benefits that Would Impact Effective Tax Rate	102,100	51,200	23,500
Other Comprehensive Income (Loss), Tax	24,900	27,100	0
Reconciliation of Unrecognized Tax Benefits, Excluding Amounts Pertaining to Examined Tax Returns [Roll Forward]
Balance as of January 1	57,615	26,627	11,274
Gross increases related to current year tax positions	59,909	27,538	7,620
Unrecognized Tax Benefits, Period Increase (Decrease)	(952)	6,464	8,305
Unrecognized Tax Benefits, Decrease Resulting from Settlements with Taxing Authorities	0	3,014	572
Balance as of December 31	116,572	57,615	26,627
Unrecognized Tax Benefits, Interest on Income Taxes Accrued	1,200
UNITED STATES
Operating Loss Carryforwards [Line Items]
Income (Loss) from Continuing Operations before Equity Method Investments, Income Taxes, Extraordinary Items, Noncontrolling Interest	1,665,087	1,101,446	795,300
Foreign
Operating Loss Carryforwards [Line Items]
Income (Loss) from Continuing Operations before Equity Method Investments, Income Taxes, Extraordinary Items, Noncontrolling Interest	$ (439,990)	$ (340,211)	$ (98,918)