Deferred Revenue (Details) - USD ($) $ in Thousands	Dec. 31, 2015	Dec. 31, 2014
Current portion:
Deferred revenue, current portion	$ 153,487	$ 74,025
Long-term portion:
Deferred revenue, long-term portion	664,679	135,249
Received or receivable from Sanofi
Current portion:
Deferred revenue, current portion	101,573	15,927
Long-term portion:
Deferred revenue, long-term portion	582,664	62,819
Received or receivable from Bayer HealthCare
Current portion:
Deferred revenue, current portion	24,290	33,652
Long-term portion:
Deferred revenue, long-term portion	31,926	15,007
Received for technology license agreement
Current portion:
Deferred revenue, current portion	23,572	23,572
Long-term portion:
Deferred revenue, long-term portion	33,851	57,423
Other
Current portion:
Deferred revenue, current portion	4,052	874
Long-term portion:
Deferred revenue, long-term portion	$ 16,238	$ 0