Property, Plant, and Equipment (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Property, Plant and Equipment [Line Items]
Land	$ 77,826	$ 2,768
Buildings and Improvements, Gross	760,517	398,981
Leasehold Improvements, Gross	95,226	42,600
Construction in Progress, Gross	579,834	472,231
Property, plant, and equipment, gross	1,925,216	1,228,293
Furniture and Fixtures, Gross	81,381	58,655
Less: accumulated depreciation and amortization	(331,096)	(253,984)
Property, plant, and equipment, net	1,594,120	974,309
Depreciation and amortization expense	74,909	52,686	$ 41,204
New Laboratory and Office Facilities
Property, Plant and Equipment [Line Items]
Costs incurred by the landlord to construct new laboratory and office facilities	254,600	236,700
Laboratory and other equipment
Property, Plant and Equipment [Line Items]
Property, plant, and equipment, gross	330,432	253,058
New land in Tarrytown, New York
Property, Plant and Equipment [Line Items]
Land	73,000
UNITED STATES
Property, Plant and Equipment [Line Items]
Property, plant, and equipment, net	1,118,400	754,700
Foreign
Property, Plant and Equipment [Line Items]
Property, plant, and equipment, net	$ 475,700	$ 219,600