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Technology Licensing Agreements (Details) - USD ($)
$ in Thousands
1 Months Ended 12 Months Ended
Aug. 31, 2010
Mar. 31, 2007
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Deferred Revenue Arrangement [Line Items]          
Technology licensing revenue     $ 74,889 $ 31,941 $ 28,506
License Agreement with Astellas Pharma Inc.          
Deferred Revenue Arrangement [Line Items]          
Non-exclusive license agreement term   6 years      
Advance payment received due to amended licensing agreement $ 165,000        
Recognition period for advance payment 7 years        
Future payment to be made under terms of amended licensing agreement     $ 130,000    
Number of days of advance written notice to terminate agreement     90 days    
Technology licensing revenue     $ 23,600 23,600 $ 23,600
Deferred Revenue     $ 57,400 $ 81,000