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Collaboration Agreements (PDGFR-beta Antibody) (Details)
$ in Thousands
12 Months Ended
Dec. 31, 2015
USD ($)
Dec. 31, 2014
USD ($)
Collaboration Agreements [Line Items]    
Accounts receivable from Bayer HealthCare $ 162,152 $ 125,483
PDGFR-beta outside the US    
Collaboration Agreements [Line Items]    
Maximum percentage of outstanding shares that may be acquired, under 'standstill' provisions 20.00%  
Percentage of global development cost to be paid by the collaboration partner under the collaboration 25.00%  
Percentage of development cost for the territory outside the United States to be paid for under the collaboration 50.00%  
Percentage of development milestone payments to be reimbursed 50.00%  
Number of development milestone payments the Company received   2
Deferred Revenue, Additions   $ 2,500
Substantive milestone payment to the Company $ 5,000  
Future development milestone payment the Company is eligible to receive 10,000  
Opt in payment 20,000  
Amount of milestone payment that may be received relating to marketing approval 20,000  
Accounts receivable from Bayer HealthCare $ 1,397 1,191
Proceeds from Collaborators   $ 25,500