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Collaboration Agreements (EYLEA) (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 12 Months Ended
Aug. 31, 2007
Oct. 31, 2006
Mar. 31, 2014
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Collaboration Agreements [Line Items]            
Period for Achieving Sales Target for Milestone Payment, Rolling Basis         12 months  
Levels of twelve month sales at which sales milestone payments were received         $ 500,000  
level of twelve months sales at which sales milestone payments maybe received - 100 million         100,000  
Accounts receivable from Bayer HealthCare       $ 162,152 125,483  
Collaboration Agreement with Bayer HealthCare LLC            
Collaboration Agreements [Line Items]            
Percentage of repayment of development balance out of profits       50.00%    
Contingent reimbursement obligation       $ 258,000    
Revenue Recognition, Milestone Method, Revenue Recognized       15,000 105,000 $ 70,000
Period for Achieving Sales Target for Milestone Payment, Rolling Basis           12 months
Levels of twelve months sales at which sales milestone payments were received - 200 million       200,000    
Research and Development Arrangement, Contract to Perform for Others, Compensation Earned       8,887 23,383 $ 20,905
Proceeds from Collaborators $ 20,000 $ 75,000        
Other Research and Development Expense       $ 13,700 18,600 15,300
Deferred Revenue, Additions $ 20,000 $ 75,000        
BRVO            
Collaboration Agreements [Line Items]            
Research and Development Arrangement, Contract to Perform for Others, Compensation Earned     $ 15,700      
Marketing Approval | Collaboration Agreement with Bayer HealthCare LLC            
Collaboration Agreements [Line Items]            
Revenue Recognition, Milestone Method, Revenue Recognized           15,000
Pricing Approval | Collaboration Agreement with Bayer HealthCare LLC            
Collaboration Agreements [Line Items]            
Revenue Recognition, Milestone Method, Revenue Recognized           10,000
starting at sales achievement - $200 million            
Collaboration Agreements [Line Items]            
Period for Achieving Sales Target for Milestone Payment, Rolling Basis       12 months    
starting at sales achievement - $200 million | Collaboration Agreement with Bayer HealthCare LLC            
Collaboration Agreements [Line Items]            
Revenue Recognition, Milestone Method, Revenue Recognized           45,000
Levels of twelve months sales at which sales milestone payments were received - 200 million           $ 200,000
starting at sales achievement - $500 million            
Collaboration Agreements [Line Items]            
Revenue Recognition, Milestone Method, Revenue Recognized         90,000  
sales achievement - 200 million            
Collaboration Agreements [Line Items]            
Maximum amount of sales milestone payments if total sales achieve specific levels         $ 15,000  
sales achievement - 100 million            
Collaboration Agreements [Line Items]            
Period for Achieving Sales Target for Milestone Payment, Rolling Basis         12 months  
Maximum amount of sales milestone payments if total sales achieve specific levels       $ 15,000