Income Taxes (Tables)

12 Months Ended

Dec. 31, 2015

Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block]

Components of income before income taxes consist of the following:



	Year Ended December 31,
	2015			2014			2013
United States	$	1,665,087		$	1,101,446		$	795,300
Foreign	(439,990		)	(340,211		)	(98,918		)
	$	1,225,097		$	761,235		$	696,382

Schedule of Components of Income Tax Expense (Benefit)

Components of income tax expense consist of the following:



		Year Ended December 31,
		2015			2014			2013
Current:
	Federal	$	686,561		$	437,038		$	196,527
	State	28,568			28,718			23,489
	Foreign	4,004			2,879			433
	Total current tax expense	719,133			468,635			220,449
Deferred:
	Federal	(119,849		)	(62,932		)	53,504
	State	(3,768		)	18,891			8,700
	Foreign	(6,475		)	(1,485		)	(9		)
	Total deferred tax (benefit) expense	(130,092		)	(45,526		)	62,195
		$	589,041		$	423,109		$	282,644

Schedule of Effective Income Tax Rate Reconciliation

A reconciliation of the U.S. statutory income tax rate to the Company's effective income tax rate is as follows:



	Year Ended December 31,
	2015		2014		2013
U.S. federal statutory tax rate	35.0	%	35.0	%	35.0	%
State and local income taxes	1.0		2.4		3.4
Change in state effective rate	(0.1	)	2.9		—
Foreign income tax rate differential	12.2		15.8		4.9
Income tax credits	(1.6	)	(5.1	)	(4.9	)
Non-deductible Branded Prescription Drug Fee	2.0		2.8		1.1
Domestic production activities deduction	(3.2	)	—		—
Other permanent differences	2.8		1.8		1.1
Effective income tax rate	48.1	%	55.6	%	40.6	%

Schedule of Deferred Tax Assets and Liabilities

Significant components of the Company's deferred tax assets and liabilities are as follows:



	As of December 31,
	2015			2014
Deferred tax assets:
Net operating loss carryforward	$	140		$	150
Fixed assets	—			8,078
Deferred revenue	51,766			60,223
Deferred compensation	349,508			216,640
Income tax credit carryforwards	—			8,539
Capitalized research and development costs	7,725			12,908
Accrued expenses	47,520			19,331
Other	26,580			21,922
	483,239			347,791
Valuation allowance	—			(359		)
Total deferred tax assets	483,239			347,432

Deferred tax liabilities:
Unrealized gains/losses on marketable securities	(3,280		)	(28,186		)
Fixed assets	(5,559		)	—
Convertible senior notes	—			(252		)
Other	(12,455		)	(3,578		)
Total deferred tax liabilities	(21,294		)	(32,016		)
Net deferred tax assets	$	461,945		$	315,416

Schedule Of Unrecognized Tax Benefits Roll Forward

The following table summarizes the gross amounts of unrecognized tax benefits. The amount of unrecognized tax benefits that, if settled, would impact the effective tax rate is $102.1 million, $51.2 million, and $23.5 million as of December 31, 2015, 2014, and 2013, respectively.



	2015			2014			2013
Balance as of January 1	$	57,615		$	26,627		$	11,274
Gross increases related to current year tax positions	59,909			27,538			7,620
Gross (decreases) increases related to prior year tax positions	(952		)	6,464			8,305
Gross decrease due to settlements, recapture, filed returns, and lapse of statutes of limitation	—			(3,014		)	(572		)
Balance as of December 31	$	116,572		$	57,615		$	26,627