Property, Plant, and Equipment

12 Months Ended

Dec. 31, 2015

Property, Plant and Equipment [Abstract]

Property, Plant and Equipment

Property, Plant, and Equipment

Property, plant, and equipment consist of the following:

	As of December 31,
	2015			2014
Land	$	77,826		$	2,768
Building and improvements	760,517			398,981
Leasehold improvements	95,226			42,600
Construction-in-progress	579,834			472,231
Laboratory and other equipment	330,432			253,058
Furniture, computer and office equipment, and other	81,381			58,655
	1,925,216			1,228,293
Less, accumulated depreciation and amortization	(331,096		)	(253,984		)
	$	1,594,120		$	974,309

As of December 31, 2015 and 2014, $1,118.4 million and $754.7 million, respectively, of the Company's property, plant, and equipment was located in the United States and $475.7 million and $219.6 million, respectively, was located in Ireland. In 2015, the Company acquired an approximate 100-acre parcel of undeveloped land adjacent to the Company's current Tarrytown, New York location for an aggregate purchase price of $73.0 million.

Depreciation and amortization expense on property, plant, and equipment amounted to $74.9 million, $52.7 million, and $41.2 million for the years ended December 31, 2015, 2014, and 2013, respectively.

Property, plant, and equipment, at cost, as of December 31, 2015 and 2014 included $254.6 million and $236.7 million, respectively, of costs incurred by the Company's landlord to construct laboratory and office facilities in Tarrytown, New York. See Note 12a.