Accounts Payable and Accrued Expenses (Details) - USD ($) $ in Thousands	Sep. 30, 2015	Dec. 31, 2014
Accounts Payable and Accrued Liabilities, Current [Abstract]
Accounts payable	$ 106,917	$ 99,508
Accrued payroll and related costs	120,933	92,778
Accrued clinical trial expense	62,569	41,555
Accrued sales-related charges, deductions and royalties	160,941	133,085
Other accrued expenses and liabilities	126,068	116,563
Accounts payable and accrued expenses	$ 577,428	$ 483,489