Accounts Payable and Accrued Expenses (Details) - USD ($) $ in Thousands	Jun. 30, 2015	Dec. 31, 2014
Accounts Payable and Accrued Liabilities, Current [Abstract]
Accounts payable	$ 130,016	$ 99,508
Accrued payroll and related costs	83,105	92,778
Accrued clinical trial expense	48,084	41,555
Accrued sales-related charges, deductions and royalties	196,095	133,085
Other accrued expenses and liabilities	72,205	116,563
Accounts payable and accrued expenses	$ 529,505	$ 483,489