CONSOLIDATED STATEMENTS OF CASH FLOWS (USD $) In Thousands, unless otherwise specified	3 Months Ended
Mar. 31, 2015	Mar. 31, 2014
Cash flows from operating activities:
Net income	$ 76,021us-gaap_NetIncomeLoss	$ 68,305us-gaap_NetIncomeLoss
Adjustments to reconcile net income to net cash (used in) provided by operating activities:
Depreciation and amortization	16,027	11,530
Non-cash compensation expense	103,759us-gaap_ShareBasedCompensation	75,785us-gaap_ShareBasedCompensation
Non-cash interest expense	2,358us-gaap_OtherNoncashExpense	5,916us-gaap_OtherNoncashExpense
Losses on Extinguishment of Debt	942	0
Other non-cash charges and expenses, net	6,006us-gaap_OtherNoncashIncomeExpense	3,761us-gaap_OtherNoncashIncomeExpense
Deferred Taxes	(10,888)	(5,761)
Changes in assets and liabilites
Increase in Sanofi, Bayer HealthCare, and trade accounts receivable	(321,063)	(92,529)
Increase in Inventories	(5,932)us-gaap_IncreaseDecreaseInInventories	(15,550)us-gaap_IncreaseDecreaseInInventories
Decrease (increase) in prepaid expenses and other assets	35,874	(20,898)
(Decrease) increase in deferred revenue	(16,140)	37,107
Increase (decrease) in accounts payable, accrued expenses and other liabilities	25,534	(14,139)
Total adjustments	(163,523)	(14,778)
Net cash (used in) provided by operating activities	(87,502)	53,527
Cash flows from investing activities:
Purchases of marketable securities	(95,775)	(253,878)
Sales or maturities of marketable securities	80,456	82,469
Capital expenditures	(114,162)	(64,822)
Net cash used in investing activities	(129,481)	(236,231)
Cash flows from financing activities:
Proceeds (payments) in connection with facility and capital lease obligations	6,738	(262)
Repayments of convertible senior notes	(16,686)us-gaap_RepaymentsOfConvertibleDebt	0us-gaap_RepaymentsOfConvertibleDebt
Payments in connection with deduction of outstanding warrants	(124,531)us-gaap_PaymentsForRepurchaseOfWarrants	0us-gaap_PaymentsForRepurchaseOfWarrants
Proceeds from issuance of Common Stock	76,273	55,042
Payments in connection with Common Stock tendered for employee tax obligations	(21,192)	(63,086)
Excess tax benefit from stock-based compensation	155,569	117,260
Net cash provided by financing activities	76,171	108,954
Net decrease in cash and cash equivalents	(140,812)	(73,750)
Cash and cash equivalents at beginning of period	648,719	535,608
Cash and cash equivalents at end of period	$ 507,907	$ 461,858

The sum of adjustments which are added to or deducted from net income or loss, including the portion attributable to noncontrolling interest, to reflect cash provided by or used in operating activities, in accordance with the indirect cash flow method.

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