CONSOLIDATED STATEMENTS OF CASH FLOWS (USD $) In Thousands, unless otherwise specified	12 Months Ended
Dec. 31, 2014	Dec. 31, 2013	Dec. 31, 2012
Cash flows from operating activities:
Net income	$ 348,074us-gaap_NetIncomeLoss	$ 424,362us-gaap_NetIncomeLoss	$ 750,269us-gaap_NetIncomeLoss
Adjustments to reconcile net income to net cash provided by (used in) operating activities:
Depreciation and amortization	52,686	41,204	36,940
Non-cash compensation expense	307,238us-gaap_ShareBasedCompensation	198,399us-gaap_ShareBasedCompensation	94,157us-gaap_ShareBasedCompensation
Non-cash interest expense	18,052us-gaap_OtherNoncashExpense	23,061us-gaap_OtherNoncashExpense	22,925us-gaap_OtherNoncashExpense
Loss on Extinguishment of Debt	33,469	0	0
Other non-cash charges and expenses, net	30,003us-gaap_OtherNoncashIncomeExpense	23,690us-gaap_OtherNoncashIncomeExpense	34,049us-gaap_OtherNoncashIncomeExpense
Increase (Decrease) in Deferred Income Taxes	(66,604)	63,601	(340,156)
Changes in assets and liabilites
Increase in Sanofi, Bayer HealthCare, and trade accounts receivable	(62,432)	(258,994)	(588,398)
Increase in Inventories	(60,900)us-gaap_IncreaseDecreaseInInventories	(47,956)us-gaap_IncreaseDecreaseInInventories	(28,932)us-gaap_IncreaseDecreaseInInventories
(Increase) decrease in prepaid expenses and other assets	(37,767)	7,571	(25,371)
Increase (decrease) in deferred revenue	19,102	(27,974)	(41,077)
Increase in accounts payable, accrued expenses and other liabilities	162,236	136,684	10,979
Total adjustments	395,083	159,286	(824,884)
Net cash provided by (used in) operating activities	743,157	583,648	(74,615)
Cash flows from investing activities:
Purchases of marketable securities	(564,188)	(577,278)	(470,945)
Sales or maturities of marketable securities	476,417	378,146	439,209
Capital expenditures	(333,006)	(156,323)	(49,337)
Net cash used in by investing activities	(420,777)	(355,455)	(81,073)
Cash flows from financing activities:
Payments in connection with facility and capital lease obligations	(1,095)	(2,024)	(2,203)
Repayments of convertible senior debt	(220,639)us-gaap_RepaymentsOfConvertibleDebt	0us-gaap_RepaymentsOfConvertibleDebt	0us-gaap_RepaymentsOfConvertibleDebt
Payments in connection with reduction of outstanding warrants	(294,552)us-gaap_PaymentsForRepurchaseOfWarrants	0us-gaap_PaymentsForRepurchaseOfWarrants	0us-gaap_PaymentsForRepurchaseOfWarrants
Proceeds from issuance of Common Stock	126,045	57,393	63,549
Payments in connection with Common Stock tendered for employee tax obligations	(267,584)	(195,087)	(163,300)
Excess tax benefit from stock-based compensation	448,556	216,857	4,308
Net cash (used in) provided by financing activities	(209,269)	77,139	(97,646)
Net increase (decrease) in cash and cash equivalents	113,111	305,332	(253,334)
Cash and cash equivalents at beginning of period	535,608	230,276	483,610
Cash and cash equivalents at end of period	648,719	535,608	230,276
Supplemental disclosure of cash flow information
Cash paid for interest (net of amounts capitalized)	20,614us-gaap_InterestPaidNet	23,842us-gaap_InterestPaidNet	21,946us-gaap_InterestPaidNet
Cash paid for income taxes	$ 59,847us-gaap_IncomeTaxesPaidNet	$ 1,057us-gaap_IncomeTaxesPaidNet	$ 0us-gaap_IncomeTaxesPaidNet

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-Subparagraph (b)

-URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3291-108585

Reference 2: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Glossary Financing Activities

-URI http://asc.fasb.org/extlink&oid=6513228

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- Definition

The cash outflow for the obligation for a lease meeting the criteria for capitalization (with maturities exceeding one year or beyond the operating cycle of the entity, if longer).

+ References

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- Definition

The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method.

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