Property, Plant, and Equipment (Details) (USD $)	12 Months Ended
Dec. 31, 2014	Dec. 31, 2013	Dec. 31, 2012
Property, Plant and Equipment [Line Items]
Land	$ 2,768,000us-gaap_Land	$ 2,768,000us-gaap_Land
Buildings and Improvements, Gross	398,981,000us-gaap_BuildingsAndImprovementsGross	343,363,000us-gaap_BuildingsAndImprovementsGross
Leasehold Improvements, Gross	42,600,000us-gaap_LeaseholdImprovementsGross	26,370,000us-gaap_LeaseholdImprovementsGross
Construction in Progress, Gross	472,231,000us-gaap_ConstructionInProgressGross	142,370,000us-gaap_ConstructionInProgressGross
Property, plant, and equipment, gross	1,228,293,000us-gaap_PropertyPlantAndEquipmentGross	748,600,000us-gaap_PropertyPlantAndEquipmentGross
Furniture and Fixtures, Gross	58,655,000us-gaap_FurnitureAndFixturesGross	44,186,000us-gaap_FurnitureAndFixturesGross
Less: accumulated depreciation and amortization	(253,984,000)	(221,617,000)
Property, plant, and equipment, net	974,309,000us-gaap_PropertyPlantAndEquipmentNet	526,983,000us-gaap_PropertyPlantAndEquipmentNet
Depreciation and amortization expense	52,686,000	41,204,000	36,940,000
New Laboratory and Office Facilities [Member]
Property, Plant and Equipment [Line Items]
Costs incurred by the landlord to construct new laboratory and office facilities	236,700,000	111,100,000
Laboratory and other equipment
Property, Plant and Equipment [Line Items]
Property, plant, and equipment, gross	253,058,000	189,543,000
UNITED STATES
Property, Plant and Equipment [Line Items]
Property, plant, and equipment, net	754,700,000	503,500,000
Foreign
Property, Plant and Equipment [Line Items]
Property, plant, and equipment, net	$ 219,600,000	$ 23,500,000

Costs incurred by the landlord to construct new laboratory and office facilities which are included in PPE

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Amount of accumulated depreciation, depletion and amortization for physical assets used in the normal conduct of business to produce goods and services.

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Amount before accumulated depreciation of building structures held for productive use including addition, improvement, or renovation to the structure, including, but not limited to, interior masonry, interior flooring, electrical, and plumbing.

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Amount of structure or a modification to a structure under construction. Includes recently completed structures or modifications to structures that have not been placed into service.

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The aggregate expense recognized in the current period that allocates the cost of tangible assets, intangible assets, or depleting assets to periods that benefit from use of the assets.

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Amount before accumulated depreciation of equipment commonly used in offices and stores that have no permanent connection to the structure of a building or utilities. Examples include, but are not limited to, desks, chairs, tables, and bookcases.

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Amount before accumulated depletion of real estate held for productive use, excluding land held for sale.

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Amount before accumulated depreciation of additions or improvements to assets held under a lease arrangement.

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Amount before accumulated depreciation, depletion and amortization of physical assets used in the normal conduct of business and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, and furniture and fixtures.

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Amount after accumulated depreciation, depletion and amortization of physical assets used in the normal conduct of business to produce goods and services and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, and furniture and fixtures.

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