Property, Plant, and Equipment

12 Months Ended

Dec. 31, 2014

Property, Plant and Equipment [Abstract]

Property, Plant and Equipment

Property, Plant, and Equipment

Property, plant, and equipment consist of the following:

	As of December 31,
	2014			2013
Land	$	2,768		$	2,768
Building and improvements	398,981			343,363
Leasehold improvements	42,600			26,370
Construction-in-progress	472,231			142,370
Laboratory and other equipment	253,058			189,543
Furniture, computer and office equipment, and other	58,655			44,186
	1,228,293			748,600
Less, accumulated depreciation and amortization	(253,984		)	(221,617		)
	$	974,309		$	526,983

As of December 31, 2014, $219.6 million of the Company’s property, plant, and equipment was located in Ireland and $754.7 million was located in the United States. As of December 31, 2013, $23.5 million of the Company’s property, plant, and equipment was located in Ireland and $503.5 million was located in the United States.

Depreciation and amortization expense on property, plant, and equipment amounted to $52.7 million, $41.2 million, and $36.9 million for the years ended December 31, 2014, 2013, and 2012, respectively.

Property, plant, and equipment, at cost, as of December 31, 2014 and 2013 included $236.7 million and $111.1 million, respectively, of costs incurred by the Company's landlord to construct laboratory and office facilities in Tarrytown, New York. See Note 13a.