Accounts Payable and Accrued Expenses (Details) (USD $) In Thousands, unless otherwise specified	Jun. 30, 2014	Dec. 31, 2013
Accounts Payable and Accrued Liabilities, Current [Abstract]
Accounts payable	$ 47,231	$ 61,936
Accrued payroll and related costs	51,786	69,429
Accrued clinical trial expense	35,498	23,654
Accrued sales-related charges, deductions and royalties	100,333	66,855
Other accrued expenses and liabilities	48,537	29,022
Accounts payable and accrued expenses	$ 283,385	$ 250,896