Accounts Payable and Accrued Expenses (Details) (USD $) In Thousands, unless otherwise specified	Mar. 31, 2014	Dec. 31, 2013
Accounts Payable and Accrued Liabilities, Current [Abstract]
Accounts payable	$ 32,692	$ 61,936
Accrued payroll and related costs	41,754	69,429
Accrued clinical trial expense	30,828	23,654
Accrued sales-related deductions and royalties	94,554	66,855
Other accrued expenses and liabilities	38,107	29,022
Accounts payable and accrued expenses	$ 237,935	$ 250,896