Property, Plant, and Equipment (Details) (USD $)	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Property, Plant and Equipment [Line Items]
Property, plant, and equipment, gross	$ 748,600,000	$ 560,453,000
Less: accumulated depreciation and amortization	(221,617,000)	(180,513,000)
Property, plant, and equipment, net	526,983,000	379,940,000
Depreciation and amortization expense	41,204,000	36,940,000	31,082,000
Impairment of Long-Lived Assets Held-for-use	500,000	2,800,000	0
Land
Property, Plant and Equipment [Line Items]
Property, plant, and equipment, gross	2,768,000	2,117,000
Building and improvements
Property, Plant and Equipment [Line Items]
Property, plant, and equipment, gross	343,363,000	328,173,000
Leasehold improvements
Property, Plant and Equipment [Line Items]
Property, plant, and equipment, gross	26,370,000	10,576,000
Construction-in-progress
Property, Plant and Equipment [Line Items]
Property, plant, and equipment, gross	142,370,000	25,076,000
Laboratory and other equipment
Property, Plant and Equipment [Line Items]
Property, plant, and equipment, gross	189,543,000	159,026,000
Furniture, computer and office equipment, and other
Property, Plant and Equipment [Line Items]
Property, plant, and equipment, gross	44,186,000	35,485,000
Assets held under capital leases
Property, Plant and Equipment [Line Items]
Property, plant, and equipment, gross	700,000	3,600,000
Less: accumulated depreciation and amortization	(200,000)	(1,100,000)
New laboratory and office facilities
Property, Plant and Equipment [Line Items]
Costs incurred by the landlord to construct new laboratory and office facilities	$ 111,100,000	$ 86,200,000