Accounts Payable and Accrued Expenses (Details) (USD $)	Mar. 31, 2013	Dec. 31, 2012	Mar. 31, 2012	Dec. 31, 2011
Accounts Payable and Accrued Liabilities, Current [Abstract]
Accounts payable	$ 24,729,000	$ 38,934,000
Accrued payroll and related costs	32,385,000	19,987,000
Accrued clinical trial expense	18,197,000	10,985,000
Accrued sales-related charges, deductions, and royalties	47,735,000	21,870,000
Other accrued expenses and liabilities	22,367,000	19,569,000
Accounts payable and accrued expenses	145,413,000	111,345,000
Accrued Capital Expenditures	$ 10,100,000	$ 8,600,000	$ 5,800,000	$ 6,200,000