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Property, Plant, and Equipment (Tables)
12 Months Ended
Dec. 31, 2012
Property, Plant and Equipment [Abstract]  
Property, Plant and Equipment
Property, plant, and equipment consist of the following:

 
As of December 31,
 
2012
 
2011
Land
$
2,117

 
$
2,117

Building and improvements
328,173

 
322,753

Leasehold improvements
10,576

 
4,479

Construction-in-progress
25,076

 
10,880

Laboratory and other equipment
159,026

 
156,397

Furniture, computer and office equipment, and other
35,485

 
29,468

 
560,453

 
526,094

Less, accumulated depreciation and amortization
(180,513
)
 
(158,139
)
 
$
379,940

 
$
367,955