CONSOLIDATED BALANCE SHEETS (USD $) In Thousands, unless otherwise specified	Dec. 31, 2012	Dec. 31, 2011
Current assets:
Cash and cash equivalents	$ 230,276	$ 483,610
Marketable securities	77,819	43,332
Accounts receivable - trade, net	593,207	28,254
Accounts receivable from Sanofi	99,913	74,781
Deferred tax assets	148,134
Prepaid expenses and other current assets	56,663	35,800
Total current assets	1,206,012	665,777
Restricted cash and marketable securities	8,186	7,721
Marketable securities	271,230	275,887
Property, plant, and equipment, at cost, net of accumulated depreciation and amortization	379,940	367,955
Deferred tax assets	192,022
Other assets	23,100	6,243
Total assets	2,080,490	1,323,583
Current liabilities:
Accounts payable and accrued expenses	111,345	95,625
Deferred revenue from Sanofi, current portion	17,022	20,011
Deferred revenue - other, current portion	33,809	31,629
Facility lease obligations, current portion	1,374	1,006
Total current liabilities	163,550	148,271
Deferred revenue from Sanofi	76,520	86,017
Deferred revenue - other	131,822	162,593
Facility lease obligations	159,436	159,508
Convertible senior notes	296,518	275,019
Other long term liabilities	7,259	6,443
Total liabilities	835,105	837,851
Commitments and contingencies (Note 13)
Stockholders' equity:
Preferred stock, $.01 par value; 30,000,000 shares authorized; issued and outstanding - none
Additional paid-in capital	1,763,508	1,754,824
Accumulated deficit	(517,054)	(1,267,323)
Accumulated other comprehensive loss	(1,166)	(1,862)
Total stockholders' equity	1,245,385	485,732
Total liabilities and stockholders' equity	2,080,490	1,323,583
Class A Stock, convertible, $.001 par value; 40,000,000 shares authorized; shares issued and outstanding - 2,069,187 at December 31, 2012 and 2,109,512 at December 31, 2011
Stockholders' equity:
Common stock	2	2
Common Stock, $.001 par value; 160,000,000 shares authorized; shares issued and outstanding - 95,223,525 at December 31, 2012 and 90,692,071 at December 31, 2011
Stockholders' equity:
Common stock	$ 95	$ 91