Property, Plant, and Equipment

12 Months Ended

Dec. 31, 2012

Property, Plant and Equipment [Abstract]

Property, Plant, and Equipment

Property, plant, and equipment consist of the following:



	As of December 31,
	2012			2011
Land	$	2,117		$	2,117
Building and improvements	328,173			322,753
Leasehold improvements	10,576			4,479
Construction-in-progress	25,076			10,880
Laboratory and other equipment	159,026			156,397
Furniture, computer and office equipment, and other	35,485			29,468
	560,453			526,094
Less, accumulated depreciation and amortization	(180,513		)	(158,139		)
	$	379,940		$	367,955

Depreciation and amortization expense on property, plant, and equipment amounted to $36.9 million, $31.1 million, and $19.7 million for the years ended December 31, 2012, 2011, and 2010, respectively. Effective in the first quarter of 2010, the estimated useful lives of certain capitalized laboratory and other equipment, which is a component of property, plant, and equipment, were extended. The effect of this change in estimate was to lower depreciation expense by $4.0 million and to lower the Company's net loss per share by $0.05 for the year ended December 31, 2010. In addition, during 2012, the Company incurred a non-cash charge of $2.8 million in connection with disposals and retirements of fixed assets. There were no material non-cash charges in connection with disposals and retirements of fixed assets in 2011 or 2010.

Included in property, plant, and equipment at both December 31, 2012 and December 31, 2011 was $3.6 million of leased equipment under capital leases, and related accumulated amortization was $1.1 million and $0.5 million at December 31, 2012 and December 31, 2011, respectively.

Property, plant, and equipment at both December 31, 2012 and 2011 includes $86.2 million of costs incurred by the Company's landlord to construct new laboratory and office facilities in Tarrytown, New York in connection with the Company's December 2006 lease, as amended, of these facilities. See Note 13a.

- Definition

The entire disclosure for long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale. Examples include land, buildings, machinery and equipment, and other types of furniture and equipment including, but not limited to, office equipment, furniture and fixtures, and computer equipment and software. This disclosure may include property plant and equipment accounting policies and methodology, a schedule of property, plant and equipment gross, additions, deletions, transfers and other changes, depreciation, depletion and amortization expense, net, accumulated depreciation, depletion and amortization expense and useful lives, income statement disclosures, assets held for sale and public utility disclosures.

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