Accounts Payable and Accrued Expenses (Details) (USD $) In Thousands, unless otherwise specified	Sep. 30, 2012	Dec. 31, 2011
Accounts Payable and Accrued Liabilities, Current [Abstract]
Accounts payable	$ 21,943	$ 27,736
Accrued payroll and related costs	46,620	42,835
Accrued clinical trial expense	11,502	9,850
Accrued sales-related deductions and royalties	21,961	3,947
Other accrued expenses and liabilities	22,198	11,257
Accounts payable and accrued expenses	$ 124,224	$ 95,625