Accounts Payable and Accrued Expenses (Details) (USD $) In Thousands, unless otherwise specified	Jun. 30, 2012	Dec. 31, 2011
Accounts payable and accrued expenses [Abstract]
Accounts payable	$ 25,672	$ 27,736
Accrued payroll and related costs	35,458	42,835
Accrued clinical trial expense	14,029	9,850
Accrued sales related deductions and royalties	36,386	3,947
Other accrued expenses and liabilities	15,223	11,257
Accounts payable and accrued expenses	$ 126,768	$ 95,625