Accounts Payable and Accrued Expenses (Details) (USD $) In Thousands, unless otherwise specified	Dec. 31, 2011	Dec. 31, 2010
Accounts payable and accrued expenses [Abstract]
Accounts payable	$ 27,736	$ 15,589
Accrued payroll and related costs	42,835	12,025
Accrued clinical trial expense	9,850	9,727
Accrued property, plant, and equipment costs	1,070	7,622
Other accrued expenses and liabilities	14,134	6,441
Payable to Bayer HealthCare	0	2,254
Accounts payable and accrued expenses	$ 95,625	$ 53,658